2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-111237
    Butyrolactone I 87414-49-1 99.80%
    Butyrolactone I is an orally active and ATP-competitive inhibitor of CDK1. Butyrolactone I inhibits NF-κB, cdc2 kinase, Bax, ROS production, modulates the PERK/CHOP. Butyrolactone I mitigates heat-stress-induced Apoptosis. Butyrolactone I shows anti-inflammatory and intestinal protective activity. Butyrolactone I has antitumor effects against non-small cell lung, small cell lung, prostate cancer and leukemia. Butyrolactone I can be used in NASH research.
    Butyrolactone I
  • HY-112247
    SR 16832 2088135-12-8 99.58%
    SR 16832 is a dual-site covalent, orthosteric and allosteric PPARγ antagonist. SR 16832 activates the TGF-β signaling pathway and upregulates the expression of Vimentin and Fibronectin (Fibronectin). SR 16832 is toxic to bronchial epithelium. SR 16832 can be used in research related to type 2 diabetes and pulmonary fibrosis.
    SR 16832
  • HY-113210
    Hydroxyphenylacetylglycine 28116-23-6 99.48%
    Hydroxyphenylacetylglycine is an acyl glycine, and an endogenous human metabolite.
    Hydroxyphenylacetylglycine
  • HY-113232
    3-Methylcrotonylglycine 33008-07-0
    3-Methylcrotonylglycine is an acyl glycine, a normal amino acid metabolite found in urine.
    3-Methylcrotonylglycine
  • HY-113450
    10Z-Nonadecenoic acid 73033-09-7 ≥99.0%
    10Z-Nonadecenoic acid is a kind of long-chain fatty acid with anti-tumor activity.
    10Z-Nonadecenoic acid
  • HY-113451
    3-Hydroxysebacic acid 73141-46-5 ≥98.0%
    3-Hydroxysebacic acid is an endogenous metabolite present in Urine that can be used for the research of Medium Chain Acyl Co A Dehydrogenase Deficiency.
    3-Hydroxysebacic acid
  • HY-116193
    5-PAHSA 1481636-41-2 99.97%
    5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics.
    5-PAHSA
  • HY-116247
    ST247 1356497-91-0 99.88%
    ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ.
    ST247
  • HY-116568
    Prothioconazole 178928-70-6 99.52%
    Prothioconazole is an orally active broad-spectrum fungicide. Prothioconazole weakly inhibits CaCYP51 activity in Candida albicans, with an apparent IC50 of approximately 120 μM. Prothioconazole disrupts Microtubule stability by reducing the acetylation level of α-tubulin. Prothioconazole induces Mitochondrial dysfunction, oxidative stress, DNA damage, and Apoptosis. Prothioconazole accumulates 14-methylated sterols and depletes ergosterol in cells, culture media, plants, and animals. Prothioconazole interferes with pyruvate metabolism and glycolysis/gluconeogenesis processes in mouse liver, downregulates Fasn mRNA expression, and induces hepatotoxicity and renal metabolic disorders. Prothioconazole reduces the fertility of female mice. Prothioconazole inhibits body weight gain and increases liver/kidney indices in mice. Prothioconazole can be used in studies related to candidiasis.
    Prothioconazole
  • HY-117430
    Hymeglusin 29066-42-0 ≥98.0%
    Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme.
    Hymeglusin
  • HY-117623
    PF-06685249 1467059-70-6 98.00%
    PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 improves renal function in ZSF-1 rats with diabetic nephropathy. PF-06685249 can be used for diabetic nephropathy research.
    PF-06685249
  • HY-118567
    Bis(maltolato)oxovanadium(IV) 38213-69-3 ≥99.0%
    Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer.
    Bis(maltolato)oxovanadium(IV)
  • HY-120034
    NCGC 607 1462267-07-7 99.77%
    NCGC 607 is a noninhibitory small-molecule chaperone of glucocerebrosidase (GCase). NCGC 607 can increase GCase activity, reduce α-synuclein levels, and decrease glycolipid levels. NCGC 607 can be used in the research of Gaucher disease and Parkinson's disease.
    NCGC 607
  • HY-120669
    PF-06761281 1854061-19-0 99.52%
    PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 µM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively.
    PF-06761281
  • HY-120968
    Arachidoyl ethanolamide 94421-69-9 98.3%
    Arachidoyl Ethanolamide (N-(2-hydroxyethyl)-eicosanamide) is an ester product.
    Arachidoyl ethanolamide
  • HY-121577
    Sonlicromanol 1541170-75-5 98.65%
    Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease.
    Sonlicromanol
  • HY-122266
    Orcein 1400-62-0
    Orcein is an irreversible stain that specifically targets elastic fibers and can interact hydrophobically with the protein components in elastic fibers. Orcein makes elastic fibers in tissues appear purple or purple-red. Orcein can be used for morphological studies of Drosophila polytene chromosomes and for qualitative and quantitative analysis of elastic fibers, collagen fibers and other components in atherosclerotic plaques.
    Orcein
  • HY-126357
    Palmitoylcarnitine 1935-18-8 99.97%
    Palmitoylcarnitine is an endogenous metabolite.
    Palmitoylcarnitine
  • HY-129398
    Formiminoglutamic acid 816-90-0 ≥99.0%
    Formiminoglutamic acid, an endogenous metabolite, could be an index of folic-acid deficiency.
    Formiminoglutamic acid
  • HY-131501
    Menaquinone 9 523-39-7 98.0%
    Menaquinone 9 is a vitamin K2 (HY-109569) analog. Menaquinone 9 acts as a prothrombogenic agent and functional electron transfer component in nitrate reductase.
    Menaquinone 9
Cat. No. Product Name / Synonyms Application Reactivity